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Syllabus Sample Benchmarks

Verified practice questions for GPAT Pharmacology Questions Part 3. Review these sample modules to test your foundational knowledge.

Q1

Unit of Km in enzyme kinetics:

AUnitless
BM⁻¹
CM
DM s⁻¹
View Answer & Rationale

Correct Answer Node:

M

Academic Rationale:

The Michaelis constant (Km) represents the substrate concentration at which the reaction velocity is half of the maximum velocity (Vmax). Therefore, Km has units of concentration, such as M, mM, or μM.

Q2

When [S] = Km, the velocity of an enzyme-catalyzed reaction is about:

A0.1 × Vmax
B0.2 × Vmax
C0.3 × Vmax
D0.5 × Vmax
View Answer & Rationale

Correct Answer Node:

0.5 × Vmax

Academic Rationale:

According to the Michaelis-Menten equation, when the substrate concentration equals Km, the reaction velocity is exactly one-half of the maximum velocity (Vmax).

Q3

Cholesterol and fatty acids absorbed from the intestinal lumen are packaged into which types of lipoproteins and secreted from the enterocytes into the lymph?

AChylomicrons and HDL
BChylomicrons and VLDL
CHDL and LDL
DVLDL and HDL
View Answer & Rationale

Correct Answer Node:

Chylomicrons and VLDL

Academic Rationale:

Dietary lipids absorbed by intestinal enterocytes are primarily packaged into chylomicrons. Small amounts of VLDL-like lipoproteins may also be formed before secretion into the lymphatic system.

Q4

Deficiency of an enzyme called branched-chain alpha-keto acid dehydrogenase causes buildup of amino acids in the body and nerve damage results. The disease is known as:

AGaucher disease
BPhenylketonuria
CFabry disease
DMaple Syrup Urine Disease
View Answer & Rationale

Correct Answer Node:

Maple Syrup Urine Disease

Academic Rationale:

Maple Syrup Urine Disease (MSUD) results from deficiency of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, causing accumulation of leucine, isoleucine, and valine, which leads to neurological damage and the characteristic sweet-smelling urine.

Q5

Bedaquiline is used in the treatment of:

AMalaria
BLeishmaniasis
CTuberculosis
DYellow fever
View Answer & Rationale

Correct Answer Node:

Tuberculosis

Academic Rationale:

Bedaquiline is a diarylquinoline antimycobacterial drug indicated for multidrug-resistant tuberculosis (MDR-TB). It acts by inhibiting mycobacterial ATP synthase.

Registry Node: qamREoNSzAzvBYLswbBI

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